产品信息 MAPK属于一种Ser/Thr蛋白激酶,可在多种不同的信号转导途径中充当一种共同的信号转导成份,且在细胞周期调控中发挥重要的作用。MAPK信号通路包括:MAP激酶(MAPK)、MAPK激酶(MEK、MKK或MAPK 激酶)和MEK激酶(MEKK、MKKK或MAPK激酶激酶)。在哺乳动物机体中,已经发现五种不同的MAPK信号转导通路。其中ERK1/2信号转导通路调控细胞生长和分化,JNK和p38 MAPK信号转导通路在炎症与细胞凋亡等应激反应中发挥重要作用。 PD 0325901: A selective inhibitor against purified MEK, exhibiting a Ki of 1 nM against activated MEK1 and MEK2. It has been shown that 1 µM PD0325901 combined with 3 µM CHIR99021 (2i) prevents cell differentiation and sustains self-renewal of murine embryonic stem cells. N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE Ref: Barret, S.D., Bridges, A.J., Dudley, D.T., et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett 18 6501-6504, 2008. Ying, Q., Wray, J., Nichols, J., et al. The ground state of embryonic stem cell self-renewal. Nature 453 519-524, 2008. Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request. Biological Activity: Not determined. 重庆市华雅干细胞技术有限公司 |